Platelet-Rich Plasma is a result of double spin method — a hard spin to separate red blood cells from everything else in the autologous (or whole) blood and a soft spin to separate the platelets and white blood cells. The result is Platelet-Rich Plasma (PRP), Platelet-Poor Plasma (PPP) and Red Blood Cells.
PRF is a newer method that we often use here and suggest. Sort of the PRP 2.0, if you will. In PRF, after the first centrifugation, the middle layer is taken—which contains less platelets but more clotting factors. This gradually forms into a fibrin network and traps in the cytokines. It is then centrifuged in a PRF centrifuge resulting in PRF, a fibrin layer containing platelets and plasma.
The biggest and best difference the clients are seeing with the PRF is that there is much less swelling and downtime for the patient.